By now, almost everyone knows about ALS (Lou Gehrig's Disease). Many have had the misfortune of direct experience with the disease. Suffice it to say that it is a devastating and dreadful disease. We are comitted to eradicating it.
ALS is not incurable. Rather, it is underfunded. The Tri State Trek provides a meaningful portion of the annual budget of the ALS Therapy Development Institute (ALS-TDI). ALS-TDI is the world's foremost drug discovery center focused exclusively on ALS. Pioneering the "biotech model," ALS-TDI places the patient at the center of every decision made in the lab. The team of scientists at ALS-TDI collaborates daily in the lab and through pharmaceutical company partnerships worldwide to discover cures and treatment for ALS.
Just since I began riding in the Tri State Trek ALS-TDI has deveoped a novel antibody known as AT-1501, which acts in a highly targeted disease specific way to tamp down the immune system. This potential therapeutic has been extensively screened and is now ready for clinical trial. Currently, it is being evaluated for safety in non-human primates after demonstrating very promising signs in laboratory mice. The estimated cost of the Phase 2 portion of this trial is a whopping $30 million.
Last summer our team, Team Bannon-Crush ALS, raised more than $200,000.00 in contributions to the Tri State Trek. The total amount of donations raised by all teams approached $1 million. This year (the tenth for our team) we have set a lofty goal of $300,000.00 for the team and $1.5 million for the ride itself. This can only happen through the generosity and compassion of our wonderful donors.
While I have not had a relative diagnosed with ALS, I have clearly been impacted by the disease through the people I have met who are associated with the Tri State Trek and ALS TDI. The riders and those they ride for, as well as the doctors and staff at ALS TDI, are truly inspirational. It is rewarding to see our team grow and our fund raising efforts flourish for such a worthwhile cause. This is the only cause for which you will ever receive a fundraising plea from me.
The 270 mile, three-day bike ride, from Boston to Greenwich, CT, takes place June 22-24, 2018. I am asking that you support me as we make our way through the winding hills of Massachusetts and Connecticut. Your contribution will place your name on the list of recipients of my daily ride updates, as I share this wonderful experience with you.
Please be as generous as you can. And please take a moment to view the inspirational video attached describing this epic ride. I hope that you will find this to be a worthwhile cause. Thank you, in advance, for your support.
Riding for a cure,